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treatment for toluene toxicity

Toluene naturally occurs in crude oil at low levels and, as such, toluene is typically generated during the process of making fuels from crude oil. 8.6.4: Toluene toxicity. Mild to moderate exposure requires no significant measures and symptoms pass in a short period of time. Toluene may also cause significant renal damage especially with chronic use. Toluene is a hydrocarbon, C 6 H 5 CH 3, also known as toluol and methyl benzene.It is a colorless, highly refractive inflammable liquid obtained from tolu and other resins and from coal tar. Toluene (methylbenzene, toluol, phenylmethane) is an aromatic hydrocarbon (C7 H8) commonly used as an industrial solvent for the manufacturing of paints, chemicals, pharmaceuticals, and rubber. Laboratory testing for acute toluene toxicity is hampered by the fact that blood tests for toluene and urinary tests for hippuric acid are not available in most hospitals. This process results in the loss of the cations Mg2þ and Ca2þ as well as other small molecules. Exposure to toluene may occur from breathing ambient or indoor air affected by such sources. The central nervous system (CNS) is the primary target organ for toluene toxicity in both humans and animals for acute (short-term) and chronic (long-term) exposures. List of known side effects. Toluene toxicity is a clinical diagnosis, although serum toluene and urine hippuric acid have been described as diagnostic measures. Treatment for Exposure and Toxicity. View non-human toxicity values for 2,4-toluene diisocyanate in WISER. Hypokalemic paralysis and renal failure are life-threatening complications. The prognosis of Toluene Poisoning is dependent on the amount of substance consumed, time between consumption and treatment, severity of the symptoms, as well as general health status of the patient If the individual can recover from the symptoms, with appropriate medication and early support, the outcome is generally good Context: Toluene inhalation is a common form of drug abuse throughout the world. Severe acute and chronic exposure requires supportive measures such as : Inhalation of toluene (eg by 'glue-sniffing') may cause either a high anion-gap or a normal anion gap acidosis. There is no specific medication for treating toluene toxicity. It is identified as CAS#108-88-3, and the United Nations Department of Transportation's number for toluene is UN#1294. Acute toluene toxicity causes neurological changes as well as various metabolic alterations. The high anion gap is probably a consequence of its metabolism to hippuric acid. These disorders have different treatments and differentiation is important. Toluene is added to gasoline, used to produce benzene, and used as a solvent. Therefore, awareness should be lent to toluene … Toxicity is apparently due to the interaction of toluene with the cytoplasmic membrane. 16,20 In our case, diagnostic delay and improper sample handling rendered these tests inconclusive. It boils at 110.4 C. and has an odor similar to that of benzene. Patients with toluene toxicity may initially be suspected of having ethylene glycol toxicity especially as the presentation may be similar (eg a patient with mental obtundation, appearance of intoxication and a metabolic acidosis). The physiological basis of toluene toxicity in relation to the activated sludge microorganisms, however, remains poorly characterized. 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